【增视能脑视觉科普】眼科专家与增视能团队在国际期刊联合发表关于“用增强现实推拉模型改善青光眼患者的视力和视觉表现”的研究论文

用增强现实推拉模型改善青光眼患者的视力和视觉表现

★原 题：《Improving the Visual Acuity and Visual Performance in Glaucoma Patients with an Augmented Reality Push- pull Model》

★作者：Hang Chu, Shasha Pang, Mark D.Wiederhold, Brenda K.Wiederhold, Li Yan, Yan Lu

青光眼是全球不可逆失明的主要原因。到2020年，全球青光眼发病率预计将增加到7600万；到2040年将达到1.118亿。在人类中，超过90%的RGC轴突投射到LGN，其余10%的RGCs投射到大脑。逆行性跨突触变性是青光眼中RGC损失的原因，视觉中枢神经变性的鉴定对于青光眼的治疗具有重要意义。我们提出，在大脑区域部分损伤中幸存下来的残余神经元可能为显著的修复潜力提供生物学基础。

— 结论 —

通过结合动态立体增强现实模型、双眼抑制地形图模型和对比度推挽模型，大多数患者实现了立体视觉功能增强和视力增强，表明上述模型可以暂时激活青光眼患者的视网膜细胞功能。

BACKGROUND

Glaucoma is a leading cause of irrversible blindness worldwide.

The global incidence of glaucoma is anticipated to increase to 76 million by 2020 and 111.8 million by 2040.

In human over 90% of RGC axons project to the LGN, the remaining 10% of RGCs project to brain.

Retrograde trans-synaptic degeneration is responsible for RGC loss in glaucoma, the identification of neurodegeneration in the visual centers if the brain has important implications for the treatment of glaucoma.

We propsed that residual neurons surviving partial damage in brain regions might provide the biological substrate for significant restoration potential.

METHODS

Subjects:

27 individuals with glaucoma (mean age=62.5±7.4yrs).

Ophthalmologic examinations:

uncorrected and corrected vision, slit lamp, intraocular pressure, fundus photography, OCT, visual field, CT or MRI of the head to exclude intracranial lesions.

Assessments:

Visual acuity

Binocular visual function tests

Long-term neuroplasticity training program:

contrast push-pull model based on AR

CONCLUSIONS

By combining the dynamic stereo augmented reality model, the binocular suppression topographic map model, and the contrast push-pull model, most patients achieved stereoscopic visual function enhancement and visual acuity enhancement, suggesting that the above models can temporarily activate retinal cell function in glaucoma patients.

REFERENCES

Davis BM, Crawley L, Pahlitzsch M, Javaid F, Cordeiro MF. Glaucoma: the retina and beyond. Acta Neuropathol. 2016 Dec;132(6):807-826.

Goebel R, Muckli LARS, Kim DS (2004) Visual system. In: Hum. Nerv. Syst. Elsevier, San Diego, pp 1280–1305.

RESULTS